COMPOSITION:

DAPASIS M:

Each tablet contains Dapagliflozin Propanediol Monohydrate equivalent to Dapagliflozin 5 mg and Metformin extended-release 500 mg.

Mechanism of Action:

Dapagliflozin:

Sodium-glucose cotransporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Dapagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, dapagliflozin reduces the reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increasing urinary glucose excretion.

Metformin is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce significant hypoglycemia in either patients with type 2 diabetes or normal subjects and does not cause hyperinsulinemia.

INDICATION & USAGE:

Dapasis M is a combination of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and metformin, a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both dapagliflozin and metformin is appropriate.

 

CONTRAINDICATIONS:

Moderate to severe renal impairment.

History of serious hypersensitivity to dapagliflozin or hypersensitivity to metformin hydrochloride.

Metabolic acidosis, including diabetic ketoacidosis.

ADVERSE REACTIONS:

The most common adverse reactions associated with Dapagliflozin are female genital mycotic infections, nasopharyngitis, and urinary tract infections.

 

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