COMPOSITION:
Each film-coated tablet contains Oxaceprol…… 200 mg
DESCRIPTION:
Oxaceprol is an amino acid derivative, which has been used for decades for the symptomatic treatment of degenerative and inflammatory joint disease.
Experimental models of arthritis showed that oxaceprol reduced leukocyte extravasation, as well as the adhesion of leukocytes to capillaries. In vitro studies have shown that oxaceprol stimulates the uptake of 3H-glucosamine and 3H-proline in chondrocytes and the incorporation of 3H-proline in the macromolecular structure of the matrix of cartilage; which would be responsible for the activity on regenerating tissue.
ACTION:
The exact mechanism of action of oxaceprol is not known. It affects connective tissue metabolism and has been used in dermatology, to promote wound healing, and in rheumatic disorders. Experimental models of arthritis showed that oxaceprol reduced leukocyte extravasation, as well as the adhesion of leukocytes to capillaries. In vitro studies have shown that oxaceprol stimulates the uptake of 3H-glucosamine and 3H-proline in chondrocytes and the incorporation of 3H-proline in the macromolecular structure of the matrix of cartilage; which would be responsible for the activity on regenerating tissue.
Absorption: 3.5 hr after oral admin.
Distribution: Permeates into the synovial fluid. Bio-availability after oral admin: approx 30%.
Excretion: Via urine (exclusively, unchanged and complete). Elimination half-life: 2.2 hr.
INDICATIONS & USAGE:
Degenerative joint disorders; Inflammatory connective tissue diseases
Adult: 200 mg tid. In severe cases, initial dose can be increased to 400 mg tid. Taken before a meal, unchewed.
Elderly: Dose reduction is recommended.