COMPOSITION:
Each soft gelatin vaginal suppository contains,
Clindamycin ………………100 Mg
Clotrimazole ……………..100 Mg
Tinidazole ………………….100 Mg
DOSAGE FORM: Soft Gelatin Capsule for vaginal use only
DESCRIPTION:
Clotrimazole: Is imidazoles and has broad-spectrum anti-fungal action. It brings about its therapeutic effect by inhibiting ergosterol synthesis. Inhibition of ergosterol synthesis alters the permeability of the cell membrane of sensitive fungi and leads to structural and functional impairment of the cytoplasmic membrane. It has fungicidal action against Candida albicans, other species of Candida as well as Trichomonacidal action.
Clindamycin: is a lincosamide antibiotic, which acts primarily against gram-positive and a wide range of anaerobic bacteria. It is a congener of lincomycin. Clindamycin inhibits bacterial protein synthesis by its action at the bacterial ribosome. The antibiotic binds preferentially to the 50S ribosomal subunit and effects the process of protein synthesis. Clindamycin has antimicrobial activity against Bacteroides spp., Gardenerellavaginalis, Mobiluncus spp., Mycoplasma hominis, Peptostreptococcus spp., Haemophilus spp., and Corynebacterium.
Tinidazole: Tinidazole is a synthetic antiprotozoal agent. Tinidazole demonstrates activity both in vitro and in clinical infections against the following protozoa: Trichomonas vaginalis, Giardia duodenalis (also termed G. lamblia), and Entamoeba histolytica. Tinidazole does not appear to have activity against most strains of vaginal lactobacilli.
INDICATIONS:
In the treatment of Vulvo- vaginal infections
CONTRAINDICATIONS:
Contraindicated in women with a history of hypersensitivity to Clotrimazole, Clindamycin, or Tinidazole. It is also contraindicated in women with a history of regional enteritis, ulcerative colitis or lincomycin associated colitis (Pseudomembranous colitis)
WARNINGS AND PRECAUTIONS:
The patient should be instructed not to engage in vaginal intercourse or use of other vaginal products (such as tampons or douches) during treatment with Clindamycin. If there is a lack of response appropriate microbiological studies should be repeated to confirm the diagnosis and rule out other pathogens before instituting another course of therapy.
CLENOL FORTE is to be administered intravaginally and is not to be taken orally.
ADVERSE EFFECTS:
CLENOL FORTE Vaginal Suppositories are well tolerated locally i.e. intravaginally. In isolated cases, vaginal irritation, and itching, burning, dyspareunia and in rare cases slight urinary frequency and burning or irritation in the sexual partner have been observed. Very rarely the patient may find this irritation intolerable and in such cases, the treatment has to be stopped.
PREGNANCY, BREAST-FEEDING AND FERTILITY:
CLENOL FORTE is not recommended for use during the first 13 weeks of pregnancy or if you are trying to conceive. It is essential to consult your doctor for advice on taking this medication during the second and third trimesters of pregnancy or while breastfeeding. Your healthcare provider can provide guidance on the safety and appropriate use of CLENOL FORTE in these stages to ensure the best outcomes for both mother and child.
IMPORTANT:
Only for vaginal insertion. Not for oral use.
DISCLAIMER: All content published online is for informational purposes only. It is not intended to be a substitute for professional medical advice. Always seek the guidance of your doctor with any questions you may have regarding your health, medical condition, or any medicines.