COMPOSITION
Each hard gelatin capsule contains:
Rabeprazole ……………..……………….. 20 mg
Levosulpiride (SR) ………………………. 75 mg
RABIPOT-LS offers faster action & sustained relief in Dyspepsia and GERD
Faster acid suppression
Significantly accelerates emptying of stomach content
Improves quality of life
PHARMACOKINETICS
Absorption: the oral bioavailability of Rabeprazole is 52%, Levosulpiride is 30%. Peak plasma concentration Rabeprazole is 3.5 hrs, Levosulpiride is 3hrs
Mechanism of Action: Rabeprazole: It is a PPI. It suppresses gastric acid secretion by inhibiting the gastric H+K+ ATP ase at the secretory surface of the gastric parietal cell
Levosulpiride: It exerts prokinetic action through dual mechanism as a D2 receptor antagonist and as a 5 HT4 receptor agonist. It exerts ant-emetic action through mild 5 HT3 receptor antagonism
INDICATIONS:
Dyspepsia
GERD
IBS associated with dyspepsia
Gastroparesis Intestinal Pseudo obstruction
DOSAGE: One capsule per day in an empty stomach
CONTRA INDICATIONS
Patients with known hypersensitivity to Rabeprazole or Levosulpiride or any excipient used in the formulation
RABIPOT-LS is contraindicated during pregnancy and should not be used during breast feeding
DRUG INTERACTIONS
Elimination half-life of digoxin increases upon the administration of Rabeprazole.