COMPOSITION:

Each film coated bilayered tablet contains,

Nortriptyline …………………………..10 mg

Pregabalin (SR) ……………………..75 MG

Methylcobalamin …………………….1500 MCG

DESCRIPTION:
Nortriptyline is a tricyclic antidepressant agent used for short-term treatment of various forms of depression & neuropathic pain. It contains a tricyclic ring system with an alkyl amine substituent on the central ring. Nortriptyline blocks the presynaptic receptors of the neurotransmitters norepinephrine & serotonin thereby blocking their reuptake and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors.

Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. Recent studies have shown that Pregabalin is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury. In June 2007, Pregabalin became the first medication approved by the U.S. Food and Drug Administration specifically for the treatment of fibromyalgia

Methylcobalamin is the neurologically active form of vitamin B12. Vitamin B12 comes in forms including hydroxy-, cyano-, and adenosyl-, but only the methyl and adenosyl forms are active within the body. Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibres and regenerates damaged neurons. In a B12 deficiency, toxic fatty acids destroy the myelin sheath but high enough doses of B12 can repair it. Animal studies have shown that high doses of Methylcobalamin are effective in neuron regeneration and that there is no known toxicity at these doses.

INDICATIONS:
Moderate to Severe Neuropathic pain associated with DPN, Fibromyalgia, Sciatica and other conditions co-existing with Anxiety & Depression.

SIDE EFFECTS:
Generally well tolerated. Most common side effects are somnolence, dizziness, dry mouth and blurring of vision.

Families and caregivers of patients being treated with Nortryptyline should be alerted about the need to monitor for the emergence of agitation, irritability, unusual changes in behavior as well as the emergence of suicidality.