COMPOSITION:
Each film-coated tablet contains
Linagliptin…………………. 5 mg
DESCRIPTION:
Linagliptin is a potent, reversible, and selective inhibitor of the enzyme DPP-4 (Dipeptidyl peptidase-4) which is involved in the inactivation of the incretin hormones- glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These incretin hormones are rapidly degraded by the enzyme DPP-4. GLP-1 and GIP increase insulin biosynthesis and secretion from pancreatic beta cells in the presence of normal and elevated blood glucose levels. Furthermore, GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepatic glucose production. Linagliptin binds to DPP-4 enzyme in a reversible manner and thus leads to an increase and a prolongation of active incretin levels. Linagliptin glucose-dependently increases insulin secretion and lowers glucagon secretion thus resulting in an overall improvement in glucose homeostasis.
INDICATIONS & USAGE:
Linagliptin is indicated in adult patients with type 2 diabetes mellitus (T2DM) to improve glycemic control.
DOSAGE & ADMINISTRATION:
Once-daily or as directed by the physician. Linagliptin can be taken with or without a meal.
CONTRA-INDICATIONS:
– This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.
– Patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.