COMPOSITION

Each film-coated tablet contains:
Dienogest IP …………… 2mg
Excipients ………………. q.s

DESCRIPTION

Dinobliss is utilized in the treatment of pelvic pain associated with endometriosis. It’s a progestin, which is similar to the female hormone, and that works by suppressing the production of estrogen hormone causing endometrium.

PHARMACOLOGY

Dinobliss reduces the endogenous production of estrogen and thereby suppresses the trophic effects of estrogen on both the eutopic and ectopic endometrium. When given continuously, dienogest leads to a hyperprogestogenic and moderately hypoestrogenic endocrine environment causing initial decidualization of endometrial tissue. Additional direct antiproliferative, immunologic, and antiangiogenic effects seem to contribute to the inhibitory action of Dinobliss on cell proliferation and to the reduction of pelvic pain associated with endometriosis. Dinobliss is a novel nortestosterone derivative with no androgenic but rather an antiandrogenic activity. Despite its low affinity to the progesterone receptor, Dinobliss has a strong progestogenic effect with no significant androgenic, mineralocorticoid, or glucocorticoid activity.

INDICATION

Dinobliss is indicated for the management of pelvic pain associated with endometriosis

CONTRAINDICATIONS

Dinobliss is not recommended to be used in women with any of the conditions listed below, which are partially derived from information on other progestin-only preparations. Should any of the conditions appear during the use of Dinobliss, treatment must be discontinued immediately

  • Known or suspected pregnancy
  • Lactation
  • Active venous thromboembolic disorder
  • Arterial and cardiovascular disease, past or present (eg, myocardial infarction, cerebrovascular accident, ischemic heart disease)
  • Diabetes mellitus with vascular involvement

DOSAGE AND ADMINISTRATION

The dosage of DINOBLISS is 1 tablet taken orally every day without a break, preferably at the same time each day, with some liquid as needed. Tablets must be taken continuously regardless of any vaginal bleeding. When a strip is finished, the next one should be started the next day. This may be taken with or without food.